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This book covers the main mathematical and numerical models in computational electrocardiology, ranging from microscopic membrane models of cardiac ionic channels to macroscopic bidomain, monodomain, eikonal models and cardiac source representations. These advanced multiscale and nonlinear models describe the cardiac bioelectrical activity from the cell level to the body surface and are employed in both the direct and inverse problems of electrocardiology. The book also covers advanced numerical techniques needed to efficiently carry out large-scale cardiac simulations, including time and space discretizations, decoupling and operator splitting techniques, parallel finite element solvers. These techniques are employed in 3D cardiac simulations illustrating the excitation mechanisms, the anisotropic effects on excitation and repolarization wavefronts, the morphology of electrograms in normal and pathological tissue and some reentry phenomena. The overall aim of the book is to present rigorously the mathematical and numerical foundations of computational electrocardiology, illustrating the current research developments in this fast-growing field lying at the intersection of mathematical physiology, bioengineering and computational biomedicine. This book is addressed to graduate student and researchers in the field of applied mathematics, scientific computing, bioengineering, electrophysiology and cardiology.
Books a la Carte are unbound, three-hole-punch versions of the textbook. This lower cost option is easy to transport and comes with same access code or media that would be packaged with the bound book.
General Chemistry: Atoms First with MasteringChemistryÂ®starts from the building blocks of chemistry, the atom, allowing the authors to tell a cohesive story that progresses logically through molecules and compounds to help students intuitively follow complex concepts more logically. This unified thread of ideas helps students build a better foundation and ultimately gain a deeper understanding of chemical concepts. Students can more easily understand the microscopic-to-macroscopic connections between unobservable atoms and the observable behavior of matter in daily life, and are brought immediately into real chemistry-instead of being forced to memorize facts.
Reflecting a true atoms first perspective, the Second Edition features experienced atoms-first authors, incorporates recommendations from a panel of atoms-first experts, and follows historical beliefs in teaching chemistry concepts based and real experimental data first. This approach distinguishes this text in the market based whereby other authors teach theory first, followed by experimental data. The text's robust technology program includes new Pause/Predict videos, new simulations and animations, and tutorials written specifically to teach with an atoms-first approach in MasteringChemistry.
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That black young people have been subject to unequal treatment in the youth justice system has been the belief of some individuals and groups, reinforced, at best, by anecdotal evidence. Negative Images: A Simple Matter of Black and White? provides not only evidential weight to uphold this view but also provides some insights into the processes by which it comes about. Findings of a case study detailed in the book demonstrate how in one youth court black youths were over-represented amongst those receiving high-tariff sentencing and that this over-representation could not be explained by seriousness or persistence of offending. Whilst responsibility for differential sentencing has often been laid at the door of Magistrates, this study reveals how social work court report practice may be contributing to the situation.
This book presents a collection of expert reviews on different subcellular compartments of the cardiomyocyte, addressing fundamental questions such as how these compartments are assembled during development, how they are changed in and by disease and which signaling pathways have been implicated in these processes so far. As such, it offers the first overview of the cell biology of heart disease of its kind, addressing the needs of cell biology students specializing in vascular and cardiac biology, as well as those of cardiologists and researchers in the field of cell biology.
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